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Free USMLE practice questions
113 free questions with full explanations: 61 for Step 1 and 52 for Step 2 CK, including every past Daily Challenge. Answer them right here. No account, no trial clock.
Pick your exam
Two free sets, one per exam
Each set has questions from every organ system, written for what that exam tests.
Step 1
61 free · 1,090 in the full bank
Mechanisms, causes and pharmacology through full clinical vignettes.
Step 2 CK
52 free · 737 in the full bank
Diagnosis, next steps and management, the decisions Step 2 CK scores.
Daily Challenge archive
Every past Daily Challenge
One hard Step 1 question a day. Once the day ends, it joins the free archive with its full explanation. Play today's
- Pleural effusions Daily #37A 36-year-old woman has 6 weeks of fever, weight loss, pleuritic chest pain, and progressive shortness of breath.11 Nov 2026
- Heparin-induced thrombocytopenia with acute thrombosis in a patient with severe renal impairment Daily #36A 66-year-old man is hospitalized for treatment of a large infected leg ulcer.10 Nov 2026
- Ischemic bowel disease Daily #35A 72-year-old woman develops cramping abdominal pain and then passes a small amount of blood-streaked stool several hours after an operation complicated by prolonged…9 Nov 2026
- Seizures and epilepsy Daily #34A 46-year-old hospitalist has twice been observed to stop speaking abruptly during patient care, stare, and make repetitive chewing movements for about 1 minute.8 Nov 2026
- Transplant immunology Daily #33A 34-year-old man with acute myeloid leukemia undergoes allogeneic hematopoietic cell transplantation from an HLA-matched sibling.7 Nov 2026
- Salicylate toxicity Daily #32A 19-year-old woman is transferred to the emergency department approximately 5 hours after taking an uncertain number of tablets from a bottle used for pain relief; the…6 Nov 2026
- Health care access Daily #31A health system reviews adults with suspected Crohn disease who were referred for gastroenterology evaluation in two regions served by the same insurance plan.5 Nov 2026
- Adrenal insufficiency Daily #30A 46-year-old woman is brought to the emergency department after 2 days of vomiting and profound weakness.4 Nov 2026
- Trinucleotide repeat disorders Daily #29A 7-year-old boy is evaluated for delayed speech, learning difficulties, and limited eye contact.3 Nov 2026
- Myocarditis Daily #28A 66-year-old man with metastatic melanoma is receiving nivolumab.2 Nov 2026
- Patient-centered communication Daily #27A 69-year-old right-handed woman who recently immigrated is brought to the emergency department after abruptly becoming unable to communicate normally.1 Nov 2026
- Abnormal uterine bleeding Daily #26A 34-year-old woman is evaluated for 8 months of unpredictable uterine bleeding, with intervals ranging from 3 to 10 weeks.31 Oct 2026
- Suicide and self-harm Daily #25A 16-year-old boy is seen with his mother after telling a school counselor 1 week ago that he had considered taking all of his mother's prescription medicines after an argument.30 Oct 2026
- Viral encephalitis Daily #24A 29-year-old woman is brought to the emergency department after 2 days of fever and headache, followed by abrupt confusion, irritability, and difficulty naming familiar objects.29 Oct 2026
- Hemophagocytic lymphohistiocytosis Daily #23A 19-year-old man is evaluated after 12 days of persistent fever, fatigue, and worsening sore throat.28 Oct 2026
- Dyslipidemias Daily #22A 9-year-old boy is evaluated after a second episode of acute pancreatitis.27 Oct 2026
- Preeclampsia with severe features at 30 weeks’ gestation, with maternal and fetal status stabilized Daily #21A 29-year-old woman, gravida 1, at 30 weeks’ gestation is admitted to a tertiary perinatal center after blood pressures of 172/114 mm Hg and 168/112 mm Hg are recorded 15…26 Oct 2026
- Amenorrhea Daily #20A 32-year-old woman presents with 10 months of absent menstrual bleeding.25 Oct 2026
- Tumor suppressor genes Daily #19A 5-year-old child with no family history of eye tumors is found to have multiple retinal tumors in both eyes.24 Oct 2026
- Dyslipidemias Daily #18A 42-year-old woman is evaluated for persistently elevated cholesterol.23 Oct 2026
- Antiphospholipid syndrome Daily #17A 32-year-old woman is evaluated after an unexplained proximal deep venous thrombosis and two prior pregnancies ending in fetal death after 10 weeks’ gestation.22 Oct 2026
- Sodium and water disorders Daily #16A 46-year-old man is brought to the emergency department after 4 days of frequent watery diarrhea and repeated vomiting.21 Oct 2026
- Advance directives Daily #15A 64-year-old woman with localized colon cancer is scheduled for elective resection.20 Oct 2026
- Bone tumors Daily #14A 17-year-old boy has 8 months of progressively worsening focal lower back pain and a mild painful scoliosis.19 Oct 2026
- Thyroiditis Daily #13A 67-year-old man with recurrent ventricular tachycardia has been taking amiodarone for 9 months; cardiology considers discontinuation impractical because of his arrhythmia.18 Oct 2026
- Endometriosis Daily #12A 31-year-old woman is evaluated for 2 years of progressively worsening pelvic pain that intensifies during menstruation and pain with deep sexual intercourse.17 Oct 2026
- Menopause Daily #11A 47-year-old woman brings her menstrual calendar to an appointment after receiving different interpretations of her reproductive stage from two laboratory reports.16 Oct 2026
- Patient safety Daily #10A 67-year-old woman is receiving packed red blood cells after surgery.15 Oct 2026
- Meta-analysis Daily #9A 4-year-old boy with recurrent wheezing is seen in a pediatric clinic.14 Oct 2026
- Bone lesions Daily #8A 24-year-old man is evaluated for a painful mass in his right thigh.13 Oct 2026
Index
All free questions
Grouped by exam. Each opens on its own page with the full explanation.
USMLE Step 1
- Fat-soluble vitamins
- Porphyrias
- Trinucleotide repeat disorders
- Tumor suppressor genes
- Trinucleotide repeat disorders
- Hereditary angioedema
- Immunodeficiency disorders
- Hypersensitivity reactions
- Transplant immunology
- Hemolytic anemias
- Inherited thrombophilias
- Antiphospholipid syndrome
- Hemophagocytic lymphohistiocytosis
- Ego defenses and psychodynamics
- Somatic symptom disorders
- Viral encephalitis
- Disorders of the ear
- Viral encephalitis
- Seizures and epilepsy
- Burns and wound healing
- Bacterial skin infections
- Muscular dystrophies
- Sjogren syndrome
- Bone lesions
- Osteogenesis imperfecta
- Bone tumors
- Cardiomyopathies
- Complications of myocardial infarction
- Dyslipidemias
- Pulmonary embolism
- Hypoxemia
- Esophageal disorders
- Portal hypertension
- Functional gastrointestinal disorders
- Ischemic bowel disease
- Glomerular disease
- Renal neoplasms
- Hypertensive disorders of pregnancy
- Prenatal care
- Urinary incontinence
- Ovarian neoplasms
- Menopause
- Amenorrhea
- Female sexual dysfunction
- Abnormal uterine bleeding
- Endometriosis
- Klinefelter syndrome
- Testicular tumors
- Congenital adrenal hyperplasia
- Hyperprolactinemia
- Adrenal insufficiency
- Respiratory alkalosis
- Blast injury
- Zoonotic infections
- Statistical vs clinical significance
- Measures of risk
- Medical errors and disclosure
- Public health
- Patient safety
- Patient-centered communication
- Health care access
USMLE Step 2 CK
- Mendelian inheritance
- Cancer screening
- Adolescent health
- Platelet disorders
- Anxiety disorders
- Suicide and self-harm
- Eating disorders
- Neuromuscular junction disorders
- Disorders of the eye
- Intracranial hemorrhage
- Parasitic skin infections
- Bites
- Pediatric orthopedics
- Bone tumors
- Rheumatoid arthritis
- Mitral valve prolapse
- Dyslipidemias
- Hypertension
- Dyslipidemias
- Myocarditis
- Heparin-induced thrombocytopenia with acute thrombosis in a patient with severe renal impairment
- Chronic obstructive pulmonary disease
- Bronchiolitis
- Pharyngitis
- Pleural effusions
- Salicylate toxicity
- Esophageal disorders
- Constipation
- Pancreatitis
- Polyposis syndromes
- Ascites
- Acute kidney injury
- Antepartum hemorrhage
- Teratology and drugs in pregnancy
- Prenatal care
- Preeclampsia with severe features at 30 weeks’ gestation, with maternal and fetal status stabilized
- Cervical cancer
- Benign breast disease
- Prostate disorders
- Hypoglycemia
- Diabetes mellitus
- Thyroiditis
- Sodium and water disorders
- Lyme disease
- Meta-analysis
- Measures of risk
- Survival analysis
- Public health surveillance
- Quality improvement
- Health care payment models
- Patient safety
- Advance directives
About the free questions
Official sample questions are published by the USMLE program. Argonaut is not affiliated with the FSMB or NBME.
01Are these USMLE questions really free?
Yes. All 113 are free to answer, with the full explanation of every answer choice, and there's no trial clock. A new one is added every day when the previous Daily Challenge ends.
02Do I need an account?
No. Pick an answer and check it right on the page. A free account adds your stats, the Daily Challenge leaderboard and free Library chapters inside the app.
03Are these real USMLE questions?
No. They're original practice questions written to the NBME Item-Writing Guide and approved by a clinician. Real exam questions are confidential. For the official samples, use the free practice materials on usmle.org.
04How do the free questions compare with the paid bank?
They're the same quality and format: the free set is part of the bank. Full access unlocks all 1,827 questions, ARGO and the full Library for $48 once. See pricing.
05How should I use free questions?
Answer first, then read every explanation, including the ones for the choices you didn't pick. Our guide on how to review USMLE questions shows a method that works.
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