USMLE Step 2 CK · 55–65% of the exam
USMLE Step 2 CK internal medicine questions
Medicine (clinical science) makes up 55–65% of Step 2 CK on the official content outline. Medicine is the largest clinical science on Step 2 CK. Argonaut groups 330 Step 2 CK questions from the core internal medicine systems here.
Free to try
Free Step 2 CK internal medicine questions
Full explanations, no account. Each opens on its own page.
- Platelet disordersA 34-year-old woman has a platelet count of 68,000/mm3 on a routine complete blood count.AQ-1580
- Mitral valve prolapseA 24-year-old woman is evaluated after a murmur is heard during a routine examination.AQ-1518
- DyslipidemiasA 58-year-old man comes to the clinic to reestablish care.AQ-1552
- HypertensionA 46-year-old man comes to the office for follow-up after elevated blood pressure was noted at several visits.AQ-1635
- Dyslipidemias Daily #18A 42-year-old woman is evaluated for persistently elevated cholesterol.23 Oct 2026
- Myocarditis Daily #28A 66-year-old man with metastatic melanoma is receiving nivolumab.2 Nov 2026
- Heparin-induced thrombocytopenia with acute thrombosis in a patient with severe renal impairment Daily #36A 66-year-old man is hospitalized for treatment of a large infected leg ulcer.10 Nov 2026
- Chronic obstructive pulmonary diseaseA 59-year-old man who currently smokes and has a 38-pack-year history comes to the office because of gradually worsening exertional dyspnea and a daily cough productive of…AQ-1467
- BronchiolitisA 7-month-old boy is brought to the clinic in winter because of 3 days of rhinorrhea and cough.AQ-1503
- PharyngitisA 9-year-old boy is brought to the clinic because of 2 days of fever and sore throat.AQ-1519
- Pleural effusions Daily #37A 36-year-old woman has 6 weeks of fever, weight loss, pleuritic chest pain, and progressive shortness of breath.11 Nov 2026
- Salicylate toxicity Daily #32A 19-year-old woman is transferred to the emergency department approximately 5 hours after taking an uncertain number of tablets from a bottle used for pain relief; the…6 Nov 2026
- Esophageal disordersA 46-year-old man with advanced HIV infection presents with 1 week of painful swallowing.AQ-1477
- ConstipationA 62-year-old man is seen 5 days after surgery for a painful lower-extremity fracture.AQ-1575
- PancreatitisA 52-year-old man has had several episodes of acute pancreatitis over the past 6 years.AQ-1641
- Polyposis syndromesA 49-year-old woman with attenuated familial adenomatous polyposis returns for follow-up.AQ-1645
- Ascites Daily #6A 64-year-old man is evaluated for 3 weeks of progressive abdominal enlargement.11 Oct 2026
- Acute kidney injuryA 64-year-old man is evaluated for decreased urine output after 3 days of vomiting and diarrhea.AQ-1432
- HypoglycemiaA 44-year-old woman reports several episodes of sweating, tremor, and difficulty concentrating on awakening after an overnight fast.AQ-1472
- Diabetes mellitusA 52-year-old man with type 2 diabetes mellitus comes for an annual visit.AQ-1610
- Thyroiditis Daily #13A 67-year-old man with recurrent ventricular tachycardia has been taking amiodarone for 9 months; cardiology considers discontinuation impractical because of his arrhythmia.18 Oct 2026
- Sodium and water disorders Daily #16A 46-year-old man is brought to the emergency department after 4 days of frequent watery diarrhea and repeated vomiting.21 Oct 2026
- Lyme diseaseA 34-year-old woman comes to the clinic because of an enlarging rash on her thigh.AQ-1629
What to expect
What Step 2 CK asks in internal medicine questions
General guidance from the content outline and how questions on this subject are usually built.
- The next best step: which test to order, and in what order.
- Management: first-line treatment, when to escalate, and when to stop.
- Pharmacotherapy choices and the adverse effects that change them.
- Reading labs, ECG findings and imaging descriptions in context.
- Prevention: screening, vaccination and risk-factor control.
- Prognosis, and the complications you need to anticipate.
Share from the official USMLE Step 2 CK content outline, checked 11 October 2026.
Coverage
Topics in the bank
161 topics, with the number of Step 2 CK questions on each. Topics with a chapter link to the Library.
- Adrenal insufficiency9
- DyslipidemiasFree7
- Infective endocarditis7
- Pleural effusions7
- HypertensionFree5
- Acute respiratory distress syndrome4
- Anemia of chronic disease4
- Ascites4
- Congenital renal anomalies4
- Envenomation4
- Esophageal disordersFree4
- Hyperthyroidism4
- Interstitial lung disease4
- Ischemic heart disease4
- Lung cancer4
- Pericardial disease4
- Peripheral arterial disease4
- Antiphospholipid syndrome3
- Aortic aneurysm and dissection3
- Cardiac tumors3
- Celiac disease3
- Chronic obstructive pulmonary diseaseFree3
- Complications of myocardial infarctionFree3
- Congenital adrenal hyperplasiaFree3
- Congenital lung malformations3
- Familial hypocalciuric hypercalcemia3
- Hemolytic anemiasFree3
- Immunodeficiency disordersFree3
- Polycythemia3
- Polyposis syndromesFree3
- Pulmonary embolismFree3
- Acid-base disorders2
- Alcoholic liver disease2
- Arrhythmias2
- Aspiration2
- Chest trauma2
- Chronic kidney disease2
- Colorectal cancer2
- Diabetes insipidus2
- Diabetes mellitusFree2
And 121 more topics with fewer questions.
Keep going
Read, then practice
- Immunodeficiency disordersIn selective IgA deficiency, a negative IgA-based celiac serology result may be falsely reassuring. Use an IgG-based celiac antibody test instead.Free chapter
- Hemolytic anemiasExplain how IgG coating of erythrocytes leads to splenic macrophage recognition, partial membrane removal, spherocyte formation, and extravascular hemolysis.Free chapter
- Platelet disordersWhen an unexpectedly low platelet count is accompanied by platelet clumping on an EDTA-sample smear, repeat the platelet count using a citrate-anticoagulated sample before diagnosing or treating thrombocytopenia.Free chapter
- Complications of myocardial infarctionRecognize acute severe mitral regurgitation as a cause of sudden pulmonary edema and a new apical systolic murmur after myocardial infarction. Infer that an inferior infarction places the posteromedial papillary muscle at risk because it typically has a single arterial supply from the posterior descending artery.Free chapter
- DyslipidemiasFibrates activate PPAR-α and lower triglycerides partly by increasing lipoprotein lipase activity. Complete lipoprotein lipase deficiency removes this pathway and can limit the triglyceride response.Free chapter
- HypertensionIn an overweight adult with established hypertension, prioritize weight loss as the lifestyle intervention with the greatest expected blood-pressure benefit. Dietary and activity changes can support weight loss or complement it.Free chapter
- Step 2 CK OB/GYN questions10–20% of Step 2 CK
- Step 2 CK psychiatry questions10–15% of Step 2 CK
Internal medicine questions, answered.
01How many Step 2 CK internal medicine questions does Argonaut have?
330 in the bank today, each a full clinical vignette with every answer choice explained. 23 of them are free to try on this page.
02How much of Step 2 CK is internal medicine content?
The official Step 2 CK content outline puts Medicine (clinical science) at 55–65% of the exam. Shares are ranges because items can count toward more than one area. Read the outline.
03Are these internal medicine questions free?
The questions listed here are free, with full explanations and no account. The rest of the Step 2 CK bank comes with Full access: $48 once, which also covers Step 1. See pricing.
04What's the best way to practice internal medicine questions?
Do a mixed block first to find your weak topics, then drill them, and read every explanation, not only the ones you missed. Our guide on reviewing USMLE questions shows how. In Full access, ARGO picks those topics for you.
All 330 internal medicine questions, for $48.
Full access unlocks the whole Step 2 CK bank and the Step 1 bank, with ARGO drilling your weakest topics.
$48 · once · Step 1 + Step 2 CK